临沂大学网络中心

韩成全

发布时间:2020-01-10动态浏览次数:10

韩成全,男,汉族,博士研究生,中共党员,山东临沂人。

教育背景

1. 2015/09–2018/12,西北农林科技大学,临床兽医学,博士,导师张涌院士

2. 2012/09–2015/06,西北农林科技大学,临床兽医学,硕士。

3. 2007/09–2012/06,西北农林科技大学, 动物医学, 学士。

科研与工作经历

2020/01-至今,临沂大学,讲师。

2018/12–2019/12,西北农林科技大学,科研助理

研究方向:

早期胚胎发育及转基因动物克隆。

主要研究论文:

1. Chengquan Han, Ruizhi Deng, Tingchao Mao, Yan Luo, Biao Wei, Peng Meng, Lu Zhao, Qing Zhang, Fusheng Quan, Jun Liu, Yong Zhang. Overexpression of Tet3 in donor cells enhances goat somatic cell nuclear transfer efficiency. FEBS Journal 2018;285:2708-2723.

2. Chengquan Han, Zhenzhen Lu, Jingcheng Zhang, Jianmin Su, Fusheng Quan, Jun Liu, Yong Zhang. Structural intrinsically disordered proteins involved in the DNA demethylation of pre-implantation embryos. Brief in bioinformatics. 2019;136:962-979.

3. Deng Ruizhi, Han Chengquan(共同第一作者), Zhao Lu, Zhang Qing, Yan Beifen, Cheng Rui, Wei Biao, Meng Peng, Mao Tingchao, Zhang Yong, Liu, Jun. Identification and characterization of ERV transcripts in goat embryos. Reproduction. 2019;157:111-122.

4. Mao Tingchao, Han Chengquan(共同第一作者), Wei Biao, Zhao Lu, Zhang Qing, Deng Ruizhi, Liu Jun, Luo Yan,Zhang Yong. Protective Effects of Quercetin Against Cadmium Chloride-Induced Oxidative Injury in Goat Sperm and Zygotes. Biological trace element research. 2018;185:344-355.

5. Mao Tingchao, Han Chengquan(共同第一作者), Deng Ruizhi, Wei Biao, Meng Peng, Luo Yan, Zhang Yong.  Treating donor cells with 2-PCPA corrects aberrant histone H3K4 dimethylation and improves cloned goat embryo development. Systems biology in reproductive medicine. 2018;64:174-182.

6. Zhenzhen Lu, Chengtu Zhang, Chengquan Han, Quanli An, Yuyao Cheng, Yongzhong Chen, Ru Meng, Yong Zhang, and Jianmin Su.  Plasticizer bis(2-ethylhexyl) phthalate causes meiosis defects and decreases fertilization ability of mouse oocytes in vivo. Journal of Agricultural and Food Chemistry67(12) (2019) 3459-3468.

7. Mingning Qiu, Fusheng Quan, Chengquan Han, Bin Wu, Jun Liu, Zhongcai Yang, Feng Su, Yong Zhang.  Effects of granulosa cells on steroidogenesis, proliferation and apoptosis of stromal cells and theca cells derived from the goat ovary. Journal of Steroid Biochemistry and Molecular Biology 2013;138:325-333.

8. Mingning Qiu, Jun Liu, Chengquan Han, Bin Wu, Zhongcai Yang, Feng Su, Fusheng Quan, Yong Zhang. The Influence of Ovarian Stromal/Theca Cells During In Vitro Culture on Steroidogenesis, Proliferation and Apoptosis of Granulosa Cells Derived from the Goat Ovary. Reproduction in Domestic Animals. 2014;49:170-176.

9. Jun Liu, Yan Luo, Hengtao Ge, Chengquan Han, Hui Zhang, Yongsheng Wang, Jianmin Su, Fusheng Quan, Mingqing Gao, Yong Zhang. Anti-Bacterial Activity of Recombinant Human beta-Defensin-3 Secreted in the Milk of Transgenic Goats Produced by Somatic Cell Nuclear Transfer. PLOS ONE. 2013;8

10. 邱明宁,韩成全,杨忠财,刘军,权富生,张涌。山羊卵巢间质细胞对小腔卵泡发育的影响。畜牧兽医学报. 2013, 44(7)  

授权专利:

1. 一种基于供体细胞DNA甲基化水平的修饰提高山羊克隆效率的载体、细胞及方法. 授权公告号:CN 107988257 B,授权公告日:2019.02.01发明人:张涌,刘军,韩成全(撰写)等。

主要参与研究项目:

1. 国家自然科学青年基金:Tet3蛋白在山羊早期胚胎DNA甲基化重编程过程中的作用31302045,主要参与人。

2. 国家自然科学基金:内源性逆转录病毒元件转录激活调控山羊早期胚胎发育的功能研究(31772689),参与人。