张兴林

时间:2021-02-06 作者: 来源: 浏览:12599 审核:

基本信息

姓名:张兴林

国家重点人才项目入选者(青年)、山东省泰山学者特聘教授、浙江省特聘专家、欧盟(荷兰)Rubicon学者、山东省高等学校优秀青年创新团队带头人,曾获国务院特殊津贴、山东省优秀科技工作者、淮海科学技术奖科技英才奖,以及临沂市五一劳动奖章等荣誉奖励及称号。

性别:男

民族:汉族

籍贯:山东临沂

政治面貌:中共党员

学位:博士

职称:教授

邮箱:zhangxinglin@lyu.edu.cn

 

教育经历

1. 2000/09 - 2005/06,中国农业大学动物医学院,动物医学专业,学士

2. 2005/09 - 2008/07,中国农业大学动物医学院,预防兽医学专业,硕士

3. 2005/09 - 2008/07,荷兰乌特勒支大学(Utrecht  University)医学中心(UMC),微生物专业,博士

 

科研与学术工作经历

1. 2018/6-至今,临沂大学,农林科学学院,教授

2. 2016/06 - 2018/06,浙江大学,生物系统工程与食品科学学院,研究员(正高级),博士生导师

3. 2014/09 - 2016/06,英国牛津大学(University of Oxford),博士后,Rubicon Fellow

4. 2013/04 - 2014/08,荷兰乌特勒支大学(Utrecht University),博士后

 

教授课程

兽医微生物学(2020至今)、动物医学研究进展(2020至今)

 

研究方向

主要从事病原微生物耐药和致病机制研究、功能基因组学研究、新型生物制品(新型疫苗、诊断试剂以及抗菌素)的研发以及等新型微生物技术的开发等微生物与宿主健康相关领域的工作。

 

主持或参加科研项目情况

1. 山东省自然基金重大基础研究项目,ZR2019ZD21,奶牛乳腺炎病原学研究及新型疫苗研制,2019.12-2024.12200万,在研,主持;

2. 山东省泰山学者特聘专家项目,肠球菌细菌素的高通量筛选2019.08-2024.08200万,在研,主持;

3. 山东省高等学校青年创新团队项目,2019KJF011,细菌性奶牛乳腺炎新型疫苗研究,2019.10-2022.10,20万,在研,主持;

4. 国家十三五重点研发计划子课题,2018YFC1200100,突发急性和烈性传染病临床救治关键技术研究,2018.08-2021.06110万元,在研,主持;

5. 国家重点人才项目(青年),2017.10-2020.10200万元,已结题,主持;

6. 欧盟荷兰科研组织NWO Rubicon项目,825.14.010Comprehensive analyses of the essential genome and the virulence determinants of Yersinia enterocolitica(小肠结肠炎耶尔森菌的必须基因和致病因子研究),2014.09-2016.09157600欧元,已结题,主持;

7. 欧盟第六框架计划预防和控制多重耐药肠球菌项目 European Union Sixth Framework Programme “Approaches to Control multi-resistant Enterococci (ACE): Studies on molecular ecology, horizontal gene transfer, fitness, and prevention” under contract LSHE-CT-2007-037410,参与;

8. 欧盟第七框架计划细菌耐药性的进化和传播项目 European Union Seventh Framework Programme (FP7-HEALTH-2011-single-stage) “Evolution and Transfer of Antibiotic Resistance” (EvoTAR) under grant agreement number 282004,参与;

9. 荷兰科研组织(NWOVINI 项目Functional genomics of Enterococcus faecium.参与;

10. 荷兰科研组织(NWOVIDI 项目From harmless gut commensal to antibiotic-resistant hospital bug,参与;

11. 英国 Wellcome Trust项目Bacterial immune evasion,参与;

 

发表的论文及著作

2020

Liu. X,Shu. Q,Chen. Q,Pang. X,Wu.Y,Zhou. W,Wu. Y,Niu. J†,Zhang. X†,Antibacterial Efficacy and Mechanism of Mannosylerythritol Lipids-A on Listeria monocytogenes, Molecules.2020 Oct 21共同通讯)

Peikun Wang, jianrui Niu, Cong Xue, Zhaoqing Han, Amro Abdelazez, Xinglin Zhang*, Two novel recombinant avian leukosis virus isolates from Luxi gamecock chickens, Archives of Virology, 2020.12, 165:(12):2877-2881*通讯作者)

Wanyi Zhou, Jingjin Hu, Xinglin Zhang†, Qihe Chen†, Application of bamboo leaves extract to Chinese yellow rice wine brewing for ethyl carbamate regulation and its mitigation mechanism, Food Chemistry, 2020, 319:126554.共同通讯)

2019

Ruppe E, Ghozlane A, Tap J, Pons N, Alvarez AS, Maziers N, Cuesta T, Hernando-Amado S, Clares I, Martinez JL, Coque TM, Baquero F, Lanza VF, Maiz L, Goulenok T, De Lastours V, Amor N, Fantin B, Wieder I, Andremont A, Van Schaik W, Rogers M, Zhang X, Willems RJL, De Brevern AG, Batto JM, Blottiere HM, Leonard P, Lejard V, Letur A, Levenez F, Weiszer K, Haimet F, Dore J, Kennedy SP, Ehrlich SD. Prediction of the intestinal resistome by a three-dimensional structure-based method [J]. Nat Microbiol, 2019, 4(1): 112-23.

2018

B. Peng†, X. Zhang†,  D.G.A.L. Aarts and R. Dullens. 2018. Superparamagnetic colloidal nickel nanocrystal clusters with antibacterial activity and bacteria binding ability. Nat Nanotechnol 13, pages478–482 (2018)IF38.9(†:共同第一作者)

2017

X. Zhang, V. de Maat, A.M. Guzmán, T.K. Prajsnar, J.R. Bayjanov, M. de Been, M. R.C. Rogers, M. J.M. Bonten, S. Mesnage, R. J.L. Willems, W. van Schaik. 2017. RNA-seq and Tn-seq reveal fitness determinants of vancomycin-resistant Enterococcus faecium during growth in human serum. BMC Genomics 18 (1), 893(第一作者)

A.M. Guzmán, J. Wijngaarden, J.C. Braat, MRC Rogers, Majoor E, E.C. Brouwer, X. Zhang, J.R. Bayjanov, M.J.M. Bonten, R.J.L. Willems, W. van Schaik. 2017. The Two-Component System ChtRS Contributes to Chlorhexidine Tolerance in Enterococcus faecium. Antimicrob Agents Chemother 61(5). pii: e02122-16.

2016

F.L. Paganelli, J. Huebner, K.V. Singh, X. Zhang, D. Wobser, J.C. Braat, B.E.M. Murray, J.M. Bonten, R.J.L. Willems, H.L. Leavis. 2016. Identification of Phosphoenolpyruvate-Phosphotransferase system permease BepA involved in Enterococcus faecium endocarditis and biofilm formation by a genome-wide screening approach. J Infect Dis 15;214(2):189-95..

2015

A.M. Guzmán, R.T. Urbanus, X. Zhang, D. Bierschenk, A. Koekman, M. van Luit-Asbroek, J.P. Ouwerkerk, M. Pape, M. Roest, M.J.M. Bonten, R.J.L. Willems, W. van Schaik. 2015. The N-terminal domain of the thermo-regulated surface protein PrpA of Enterococcus faecium binds to fibrinogen, fibronectin and platelets. Sci. Rep 17;5:18255.

R. Ladjouzi, A. Bizzini, W. van Schaik, X. Zhang, A. Rincé, A. Benachour, A. Hartke. 2015. Loss of antibiotic tolerance in Sod-deficient mutants is dependent on the energy source and arginine catabolism in enterococci. J Bacteriol DOI: 10.1128/JB.00389-15

2013

X. Zhang *, M. Rogers, D. Bierschenk, M. J. Bonten, R. J. Willems, W. van Schaik. 2013. A LacI-family regulator activates maltodextrin metabolism of Enterococcus faecium. PLoS One 8(8): e72285. doi:10.1371/journal.pone.0072285. *通讯作者)

X. Zhang *, D. Bierschenk, J. Top, I. Anastasiou, M. J. Bonten, R. J. Willems, and W. van Schaik. 2013. Functional genomic analysis of bile salt resistance in Enterococcus faecium. BMC Genomics 14:299 doi: 10.1186/1471-2164-14-299. *通讯作者)

J. Top, F.L.Paganelli, X. Zhang, W. van Schaik, H.L. Leavis, M. van Luit-Asbroek, T. van der Poll, M. Leendertse, M. J. Bonten, R. J. Willems. 2013. The Enterococcus faecium enterococcal biofilm regulator, EbrB, regulates the esp operon and is implicated in biofilm formation and intestinal colonization. PLoS One 8 (5), e65224.

X. Zhang, J. Top, M. de Been, D. Bierschenk, M. Rogers, M. Leendertse, M. J. Bonten, T. van der Poll,  R. J. Willems, W. van Schaik. 2013. Identification of a genetic determinant in clinical Enterococcus faecium strains which contributes to intestinal colonization during antibiotic treatment. J Infect Dis 207 (11): 1780-1786. doi: 10.1093/infdis/jit076.(第一作者)

F.L.Paganelli, R. J. Willems, P. Jansen, A. Hendrickx, X. Zhang, M. J. Bonten, H.L. Leavis. 2013. Enterococcus faecium biofilm formation: identification of major autolysin AtlAEfm, associated Acm surface localization, and AtlAEfm-independent extracellular DNA release. mBio doi: 10.1128/mBio.00154-13.

2012

X. Zhang, F. L. Paganelli, D. Bierschenk, A. Kuipers, M. J. Bonten, R. J. Willems, and W. van Schaik. 2012. Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium. PLoS Genet 8:e1002804.(第一作者) 

F. Lebreton, W. van Schaik, M. Sanguinetti, B. Posteraro, R. Torelli, F. L. Bras, N. Verneuil, X. Zhang, A. Dhalluin, R. J. Willems, R. Leclercq and V. Cattoir. 2012. AsrR is an Oxidative stress sensing regulator modulating Enterococcus faecium opportunistic traits, antimicrobial resistance and pathogenicity. PLoS Pathog 8(8): e1002834.

2011

X. Zhang, J. E. Vrijenhoek, M. J. Bonten, R. J. Willems, and W. van Schaik. 2011. A genetic element present on megaplasmids allows Enterococcus faecium to use raffinose as carbon source. Environ Microbiol 13:518-28.(第一作者) 

2009

X. Zhang, J. Ren, N. Li, W. Liu, and Q. Wu. 2009. Disruption of the BMEI0066 gene attenuates the virulence of Brucella melitensis and decreases its stress tolerance. Int J Biol Sci 5:570-7.(第一作者)

2007

Y. L. Cong, J. Pu, Q. F. Liu, S. Wang, G. Z. Zhang, X. L. Zhang, W. X. Fan, E. G. Brown, and J. H. Liu. 2007. Antigenic and genetic characterization of H9N2 swine influenza viruses in China. J Gen Virol 88:2035- 41.

2005

J. Liu, H. Xiao, F. Lei, Q. Zhu, K. Qin, X. W. Zhang, X. L. Zhang, D. Zhao, G. Wang, Y. Feng, J. Ma, W. Liu, J. Wang, and G. F. Gao. 2005. Highly pathogenic H5N1 influenza virus infection in migratory birds. Science 309:1206.

 

授权专利

1. 吴清民、牛建蕊、刘文娟、任婕、李娜、张兴林、杨羽、刘文晓、王真、张春燕  专利名称:一种带有免疫标记的羊种布鲁氏菌的重组菌及其应用。专利号:ZL 200810224817.1

2. 吴清民、牛建蕊、刘文娟、任婕、张兴林、李娜、杨羽、刘文晓、王真、张春燕  专利名称:一种羊种布鲁氏菌重组菌及其应用。专利号:ZL200810224819.0

 

其他

1.其他英文学术出版物 (书籍)

Xinglin Zhang. Functional Genomics of Enterococcus faecium: Antibiotic Resistance and Niche Adaptation. (2013; book; 国际标准书号ISBN: 978-94-6108-407-1;共52819 )

2. 国际会议报告(口头/展板):

1X.Zhang, M. Rogers, et al. Combining enrichment culturing and metagenomic sequencing: characterization of populations of enterococci and Enterobacteriaceae during antibiotic therapy. 114th ASM General Conference. 114届美国微生物协会大会美国 2014

2X.Zhang, D. Bierschenk, et al. Functional genomic analysis of bile salt resistance in Enterococcus faecium. 7th International Conference on Gram-positive Microorganisms. 第七届国际革兰氏阳性菌大会意大利 2013

3X.Zhang, J. Top, et al. Identification of a genetic determinant in clinical Enterococcus faecium strains which contributes to intestinal colonization during antibiotic treatment. Gut Day. 肠道会议比利时 2013

4X.Zhang, F. L. Paganelli, D et al. Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium. 112th ASM General Conference. 112届美国微生物协会大会美国 2012

5X.Zhang, F. L. Paganelli, D et al. Ampicillin resistance determinants of Enterococcus faecium. Annual EvoTAR meeting.  EvoTAR年会法国 2012

6X.Zhang, F. L. Paganelli, D et al. Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium. NVMM & NVvM Scientific Spring Meeting. 荷兰微生物协会春季大会荷兰 2012

7X.Zhang, I. Anastasiou, et al. Comprehensive identification of genes required for antibiotic resistance and bile tolerance in the nosocomial pathogen Enterococcus faecium.100th Anniversary NVvM & Scientific Spring Meeting. 荷兰微生物协会100周年大会荷兰 2011

8X.Zhang, I. Anastasiou, et al. Development of Microarray-based Transposon Mapping in Enterococcus faecium and its application in the identification of genes required for bile resistance. ALW Platform Molecular Genetics Annual Meeting.  ALW分子遗传学大会荷兰 2010

9X.Zhang, I. Anastasiou, et al. Development of Microarray-based Transposon Mapping (M-TraM) in Enterococcus faecium and its application in the identification of genes required for bile resistance. 3rd International ASM Conference on Enterococci. 美国微生物协会第三届肠球菌大会美国 2010

10X.Zhang, J. E. Vrijenhoek, M et al. A large conjugative plasmid confers the ability to utilize α-galactoside sugars as carbon source in E. faecium.NVMM & NVvM Scientific Spring Meeting. 荷兰微生物协会春季大会荷兰 2010

11X.Zhang, J. E. Vrijenhoek, M et al. A novel conjugative element from Enterococcus faecium involved in α-galactoside metabolism. ESCMID Conference on Enterococci. 欧洲临床微生物与传染病协会肠球菌大会西班牙 2009

12X.Zhang, J. E. Vrijenhoek et al. A novel conjugative element from Enterococcus faecium involved in α-galactoside metabolism. FEMS. 欧洲微生物协会大会瑞典 2009

13X.Zhang, J. E. Vrijenhoek, et al. Metabolism of α-galactosides in Enterococcus faecium. NVMM & NVvM Scientific Spring Meeting. 荷兰微生物协会春季大会荷兰 2009


返回原图
/